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It was recently shown that nicotine in snus acutely increases BP, and both smoking and snus has been linked with increased risk for diabetes [4, 21]

A self-administered questionnaire to measure dependence on cigarettes: the cigarette dependence scale

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In Canada, where both e-cigarettes and HTPs were available for a substantial period, e-cigarettes became legally available for sale in May 2018 7 , while IQOS was first launched in April 2017 4