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Given that smoking kills so many people who do it, the smokers who survive long enough to be at risk of Parkinsons disease might be an unusually hardy bunch, so it could be this rather than the nicotine thats protective against Parkinsons

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For immunofluorescence, organoids or cultured cells were fixed, permeabilized with 0.1% Triton X-100, blocked with 3% bovine serum albumin and incubated with primary antibodies (for example, NRF2) overnight at 4 C

Cameron SJ, Lewis KE, Huws SA, Lin W, Hegarty MJ, Lewis PD, et al