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Brain TME consists of numerous components, including non-cancerous cells such as neurons, oligodendrocytes, astrocytes, pericytes, endothelial cells, and fibroblasts, resident immune cells such as tumour-associated macrophages (TAMs), tumour infiltrating lymphocytes, and microglia and non-cellular components namely cellular signalling molecules, exosomes, secreted extracellular matrix (ECM) remodelling enzymes and other ECM components [62, 63]

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