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Approval: 2004 Indications and Usage for Pemetrexed Injection Pemetrexed Injection is a folate analog metabolic inhibitor indicated: in combination with pembrolizumab and platinum chemotherapy, for the initial treatment of patients with metastatic non-squamous non-small cell lung cancer (NSCLC), with no EGFR or ALK genomic tumor aberrations

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Various studies have been performed recently too, such as this one by the US National Library of Medicine, but there is no conclusive evidence of it working for skin lightening yet