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Su Z, et al

Challenges in the therapy of NeuroHIV As ART alone is insufficient to fully suppress HIV-1 replication, including the transcription and translation of HIV-1 provirus in both T-cell reservoirs and non-CD4 T-cell reservoirs, there is a critical need to develop new brain-penetrating agents that can effectively target both CNS and peripheral immune cells to simultaneously silence HIV-1 and reduce the risk of neuroinflammation

Not for testing and/or use on humans

Those evidence highlight the role of glutaminolysis-PHD-mTORC1 axis in cancer growth

Therefore, elucidating the mechanisms underlying drug resistance in GC and addressing unmet therapeutic needs are urgently needed