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J Plant Physiol

In December 2025, the Food and Drug Administration (FDA) approved an oral pill form of Wegovy for weight loss, and in April 2026 approved the once-daily oral GLP-1 drug Foundayo (orforglipron) also for weight loss

They are generating mice in which the protein SPHKAP can be specifically deleted from -cells, allowing them to examine how disrupting this signalling hub affects pancreatic function and GLP-1R signalling

The MTHFD2 encoded enzyme is an NAD + /NADP + -dependent enzyme that possesses 5,10-methylene-THF dehydrogenase and 5,10-methenyl-THF cyclohydrolase activities

[16] [17] However, this principle does not extend to an endorsement of combining tesamorelin with retatrutide there is no NICE guidance, NHS pathway, or published evidence base supporting this specific combination