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Vitamin B-12 status differs among pregnant, lactating, and control women with equivalent nutrient intakes. The Journal of Nutrition 145.7 (2015): 1507-1514

Retrieved February 16, 2022

What is measured in these rats and mice (and occasionally in small groups of human volunteers) is often not a hard endpoint like muscle strength or weight loss, but surrogate biomarkers: molecules in the blood that have an indirect link to a hard endpoint

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Because vitamin B12 helps the body produce brain chemicals that can affect mood and cognitive functions, a deficiency may lead to anxiety or depression