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At least three tissue-specific isozymes exist in higher vertebrates, pancreatic, hepatic and gastric/lingual

Gut-derived immune activation exacerbates central pathology in stroke and in autoimmune diseases like MS, while there is evidence that dietary interventions and probiotics can also attenuate disease severity and improve functional outcome

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Ex vivo studies showed enhanced dermal deposition with minimal surface residue, indicating localized drug reservoir formation

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