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Suggestive evidence for a new locus for epilepsy with heterogeneous phenotypes on chromosome 17q

Cotadutide (MEDI0382) is the most extensively developed dual GLP-1/glucagon receptor agonist, showing significant improvements in glucose control, BW (likely mediated by reduced energy intake rather than increased energy expenditure), hepatic fat, and albuminuria in a small RCT on patients with T2D and overweight or obesity 45,46

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ARNTL also inhibits the transcription of EGLN2 to repress ferroptosis, leading to the activation of HIF1A, a prosurvival transcription factor (Yang et al., 2019)