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If your blood levels of growth hormone are too high by virtue of injecting growth hormone, well then the pituitary can register that and the brain can register that, and then there's a negative feedback that shuts down growth hormone

Additionally, IGF-1 interacts with serotonin receptors, such as the 5-HT3 receptor, mediating neurogenesis and exhibiting antidepressant effects independent of traditional serotonin reuptake mechanisms [99]

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Inhibition of glutamine transport depletes glutamate and GABA neurotransmitter pools: Further evidence for metabolic compartmentation