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51 Following this translocation, microbial-associated molecular patterns and damage-associated molecular patterns from stressed and damaged cells can enter the liver through the portal vein, activating immune and parenchymal cells on the surfaces of toll-like and nucleotide-binding oligomerization domain-like receptors, triggering inflammatory responses, promoting hepatic fat accumulation, and accelerating liver fibrosis

Prioritize hydration with water and electrolytes to prevent both diarrhea complications and constipation

Monitor your bodys response

Certain data shows tirzepatide to be more likely to induce vomiting, while other data suggest constipation to be more associated with semaglutide