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[16] Diagnosis/testing [edit] Approximately 45% of affected individuals have mutations in either ABCC8, which encodes the protein SUR1, or KCNJ11, which encodes the protein Kir6.2

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When SCF binding to its receptor-c-KIT, it stimulates tyrosine kinase activity, resulting in receptor auto-phosphorylation to initiate signal transduction (32,33)