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ABT-737 Targets Leukemic Stem Cells In Mouse Models of Mutant NRASD12/hBCL-2- Mediated Acute Myeloid Leukemia Progression with Increased Survival

Hepatic detoxification and phase II conjugation pathways Oxidative stress and cellular redox research Neurodegeneration models (Parkinson's, Alzheimer's) Skin depigmentation and tyrosinase inhibition research Mitochondrial dysfunction and bioenergetic studies Key Findings from the Literature 01Most abundant intracellular antioxidant across human tissues 02Obligate substrate for GSTs in phase II hepatic detoxification 03GSH:GSSG ratio is an established biomarker of cellular oxidative stress 04-glutamyl linkage confers resistance to peptidase degradation 05Depletion implicated in neurodegeneration, hepatic injury, and immune dysfunction 1 Independent third-party lab reports for this peptide

J Thorac Cardiovasc Surg 112(2):341-8, 1996

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Bruinstroop E, van der Spek AH, Boelen A