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And last February, researchers from the Penn State College of Medicine reported that the active ingredient in another GLP-1, Saxenda, significantly reduced opioid cravings in a study of 20 patients with opioid use disorder

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The supervisory pharmacist who supplied this compounded drug was subsequently convicted of: racketeering, racketeering conspiracy, mail fraud and introduction of misbranded drugs into interstate commerce with the intent to defraud and mislead in connection with this fungal meningitis outbreak that led to the death of 64 patients and infection of 793 patients

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Nonetheless, several translational challenges persist, including suboptimal homing efficiency, potential immunogenicity, and uncertain long-term safety profiles in high-altitude settings