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What ties it all together is the clinical framework behind the therapy

Results Cryo-EM structure determination of OCTN2 To determine the structure of OCTN2, we overexpressed full-length human OCTN2 in HEK293F cells and isolated the transporter using a GFP-nanobody purification strategy 28

This enzyme is responsible for the oxidation of IMP to xanthosine 5-monophosphate (XMP)

Moreover, as most of the patients were on multiple ASMs it is difficult to delineate whether the reported symptomatology was secondary to either HA or polytherapy

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