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Trulicity's cardiovascular protection appears to operate through additional mechanisms beyond glycemic control including anti-inflammatory effects, improved blood vessel function, and reductions in blood pressure and triglycerides though the full picture of how dulaglutide reduces cardiovascular events is still being studied

FTO and MC4R variants relate to obesity predisposition and appetite regulation but do not directly predict semaglutide or tirzepatide response

Fast foods, saturated fats, cheeses, and greasy meats should be limited. The time of day you eat may also help

Topical numbing can be applied to the injection site

The needle dulls after a single puncture through a vial stopper, and a second use introduces both a contamination risk and a less comfortable injection