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Brain Health and Neurological Benefits Exciting research shows that GLP-1 medications may have impressive effects on brain health: They reduce the risk of Alzheimers disease and dementia They help protect against Parkinsons disease They lower the risk of seizures They may reduce stroke risk and improve recovery after stroke They show benefits for Huntingtons disease in early studies A January 2025 study from Washington University found that people taking GLP-1 medications had a decreased risk of neurocognitive disorders like Alzheimers

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Activation stimulates adenylyl cyclase via Gs, elevating intracellular cAMP and triggering protein kinase A (PKA)-mediated GH gene transcription and vesicular exocytosis