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Materials and methods: FDS2 T2D participants (n=819) had peripheral blood collected at two timepoints, baseline (2008-11) and Year 4 (2012-15), a meanSD 4.20.4 years apart, for rTL assay by quantitative PCR (intra- and inter-assay CVs 0.56% and 2.69%, respectively)

This makes perfect sense as erythrocytes take up large amounts of sphingosine and detoxify this sphingolipid by enzymatic conversion to sphingosine-1-phosphate by sphingosine kinase [124]

These bioactive peptides support collagen synthesis, reinforce the skins barrier, and help reduce early signs of dullness and fatigue

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