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The rate-limiting enzyme in this pathway is Indoleamine 2,3-dioxygenase 1 (IDO-1), which is upregulated by pro-inflammatory agents such as interferon- (IFN-) and tumor necrosis factor-alpha (TNF-), interleukin-1 (IL-1), interleukin-12 (IL-12), all cytokines that are released during inflammatory responses (Yang et al., 2024)

HUBERMAN: And as I mentioned before, you've got the options of Sermorelin and Tesamorelin, both of which are FDA approved and for which there's both animal and human data

Before using this medication, inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding

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