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The mechanistic complementarity between GHRH-class compounds (which signal through the GHRH receptor) and GHRP-class compounds like ipamorelin (which signal through the ghrelin GHSR-1a receptor) is the rationale behind the CJC-1295 + Ipamorelin combined blend, where dual-receptor stimulation produces a different GH-release profile than either compound alone

[DOI] [PMC free article] [PubMed] [Google Scholar] Gomez L.D., Noctor G., Knight M., Foyer C.H