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Proceedings of the National Academy of Sciences of the United States of America 105 (38): 1455114554

Self-prescribing high-dose B12 for weight loss is not evidence-based and may delay investigation of underlying health conditions

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Westersthl, M., Jansson, E., & Aasa, U

In fact, one study found that peoples bodies absorbed about 49% of a 1-mcg dose of cyanocobalamin, compared to 44% of the same dose of methylcobalamin ( Conversely, another study comparing the two forms reported that about three times as much cyanocobalamin was excreted through urine, indicating that methylcobalamin may be retained better within your body ( However, some research suggests that differences in bioavailability between the two forms may be insignificant and that absorption could be influenced by factors such as age and genetics ( Unfortunately, recent research directly comparing these two forms of vitamin B12 is limited