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The compound was first reported in Al-Obeidi, Castrucci, Hadley, and Hruby, J Med Chem 32 (12):255561 (1989) (PMID 2555512), building on the earlier open-chain superpotent precursor [Nle, D-Phe]--MSH reported by Sawyer, Sanfilippo, Hruby, Engel, Heward, Burnett, and Hadley in PNAS 77 (10):57548 (1980) (PMID 6777774)

Phentermine is a generic medication but it is also available as brand names Adipex-P and Lomaira

GLP-1 agonists are not recommended for people with a personal or family history of a rare genetic form of thyroid cancer or genetic syndrome called MEN2

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Mild redness or swelling may occur at the injection sites, but it usually settles within a day or two