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Methods Synthesis and characterization of EGCG-Zn nanocomplexes The synthesis steps of the EGCG-Zn nanocomplex are as follows: First, EGCG (0.2387 g, YuanYe Biotechnology Co., Ltd., Shanghai, China) was dissolved in 50 mL of N-methylpyrrolidone (NMP)

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doi: 10.1371/journal.pone.0213060 31 FardoulyJVartanianLR

This feedback loopfibrosis enabling SIBO, and SIBO amplifying fibrosistypifies the fibro-inflammatory circuit that underlies gastrointestinal involvement in SSc