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Further, GLP-1RAs promote VSMC redifferentiation via AMPK/SIRT1/forkhead box O (FOXO3a) pathways, where the expression of contractile VSMCs markers (SM22 and Calponin) is increased [125]

Notably, the American Diabetes Association advocates for the utilization of GLP-1 RAs with established cardiovascular benefits in patients diagnosed with type 2 diabetes and concurrent cardiovascular disease

Some immunobiotics can also alleviate NASH and liver fibrosis induced by a methionine-choline-deficient (MCD) diet by reducing intestinal damage and permeability in mice

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doi: 10.1111/jdi.12956 76 ZhaoQ.XuH.ZhangL.LiuL.WangL