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Mammalian cells have two distinct RNR enzymess that both share a common catalytic R1 subunit, but differ in their second subunit, with one isoform being S phase-specific and containing R2 protein and the other being expressed throughout the cell cycle as well as in post-replicative cells and having a distinct protein, p53R2, as the second subunit (Avval and Holmgren, 2009

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This reflects a key limitation: GLP-1 medications can reduce appetite and support weight loss, but they do not by themselves establish a long-term metabolic framework for maintaining that loss

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