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* * * * * (b) * * * (1) * * * (ii) * * * (A) Whether the ACO demonstrated a pattern of failure to meet both the quality performance standard and alternative quality performance standard (if applicable) or met any of the criteria for termination under 425.316(c)(1)(ii), (c)(2)(ii), or (c)(3)(ii)

rather, they decreased less than 1 percent each year, the authors reported

mechanistic mammalian studies were cited selectively to support biological plausibility