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Poly (ADP-ribose)(PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1dependent cell death (parthanatos)

During OA, synovial tissue exhibits an inflammatory response, releasing IL-1, IL-6, TNF-, and other cytokines and chemokines that attract peripheral immune cells such as macrophages, neutrophils, and T cells to the synovial membrane (145, 146)

This will give time for the immune system, the liver, and general health to improve

It makes protocol design more important, not less

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