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The core components of the mammalian Hippo pathway include the upstream large tumor suppressor (LATS) kinases (LATS1 and LATS2), mammalian Ste20-like kinases 1/2 (MST1/2), the scaffolding protein Salvador (SAV/WW45) corresponding to LATS and MST, scaffolding protein MOB domain kinase activator 1A/B (MOB1A/B), and two downstream transcriptional coactivators Yes-associated protein (YAP) and transcriptional coactivator of PDZ-binding motif (TAZ)