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Administering doses higher than natural levels may increase the risk of mortality

However, semaglutide might not suit all individuals

PMID 25387188 Raun K, et al

These medicines include semaglutide (Ozempic, Wegovy, Rybelsus), liraglutide (Victoza, Saxenda), dulaglutide (Trulicity), and tirzepatide (Mounjaro)though tirzepatide is technically a dual GIP/GLP-1 receptor agonist rather than a pure GLP-1 agonist

By redirecting electron flux and preventing excessive reduction of the respiratory chain, AOX mitigates ROS overproduction while maintaining redox balance and metabolic continuity particularly under drought, salinity, or temperature extremes