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Moreover, liraglutide treatment significantly decreased IL-6, PGE 2 and nitric oxide secretion, and the expression of inflammatory genes in vitro in chondrocytes and macrophages in a dose-dependent manner

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The glucose-dependent insulinotropic polypeptide receptor adds a second layer of metabolic regulation that amplifies fat oxidation, improves lipid metabolism, and appears to enhance the weight loss effects beyond what GLP-1 activation alone can achieve

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Furthermore, ongoing innovations in these therapies hold promise for expanded clinical applications and improved health outcomes