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Site selection: Rotate between abdomen (2+ inches from navel), outer thighs, and upper arms

Imaging studies such as plain radiographs, ultrasound, or MRI may be indicated to assess for structural joint abnormalities, inflammatory changes, or other pathology

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Pharmacology [edit] Pharmacodynamics [edit] Although the mechanism of action of valproate is not fully understood, [38] traditionally, its anticonvulsant effect has been attributed to the blockade of voltage-gated sodium channels and increased brain levels of the inhibitory synaptic neurotransmitter gamma-aminobutyric acid (GABA)